Mori L Lepore M De Libero G 2016 CD1- and MHC-related molecule-1 (MR1)-restricted T lymphocytes recognize nonpeptidic antigens, such as lipids and small metabolites, and account for a major fraction of circulating and tissue-resident T cells. They represent a readily activated, long-lasting population of effector cells and contribute to the early phases of immune response, orchestrating the function of other cells. This review addresses the main aspects of their immunological functions, including antigen and T cell receptor repertoires, mechanisms of nonpeptidic antigen presentation, and the current evidence for their participation in human and experimental diseases. https://sonar.ch/global/documents/207416 eng info:eu-repo/semantics/altIdentifier/doi/10.1146/annurev-immunol-032414-112008 info:eu-repo/semantics/altIdentifier/pmid/26927205 Annual review of immunology. - 2016 T cell receptor antigen presentation autoimmune diseases infectious diseases innate-like T cells lipid antigens metabolite antigens mucosal-associated invariant T cells natural killer T cells tumor immunity Animals Antigen Presentation Antigens Antigens, CD1 Autoimmune Diseases Histocompatibility Antigens Class I Humans Immunologic Surveillance Infections Killer Cells, Natural Lymphocyte Activation Minor Histocompatibility Antigens Natural Killer T-Cells Neoplasms Protein Binding Receptors, Antigen, T-Cell The Immunology of CD1- and MR1-Restricted T Cells. http://purl.org/coar/resource_type/c_6501