Weller M Nabors LB Gorlia T Leske H Rushing E Bady P Hicking C Perry J Hong YK Roth P Wick W Goodman SL Hegi ME Picard M Moch H Straub J Stupp R 2016 Integrins αvβ3 and αvβ5 regulate angiogenesis and invasiveness in cancer, potentially by modulating activation of the transforming growth factor (TGF)-β pathway. The randomized phase III CENTRIC and phase II CORE trials explored the integrin inhibitor cilengitide in patients with newly diagnosed glioblastoma with versus without O6-methylguanine DNA methyltransferase (MGMT) promoter methylation. These trials failed to meet their primary endpoints.Immunohistochemistry was used to assess the levels of the target integrins of cilengitide, αvβ3 and αvβ5 integrins, of αvβ8 and of their putative target, phosphorylation of SMAD2, in tumor tissues from CENTRIC (n=274) and CORE (n=224).αvβ3 and αvβ5 expression correlated well in tumor and endothelial cells, but showed little association with αvβ8 or pSMAD2 levels. In CENTRIC, there was no interaction between the biomarkers and treatment for prediction of outcome. In CORE, higher αvβ3 levels in tumor cells were associated with improved progression-free survival by central review and with improved overall survival in patients treated with cilengitide.Integrins αvβ3, αvβ5 and αvβ8 are differentially expressed in glioblastoma. Integrin levels do not correlate with the activation level of the canonical TGF-β pathway. αvβ3 integrin expression may predict benefit from integrin inhibition in patients with glioblastoma lacking MGMT promoter methylation. https://sonar.ch/global/documents/208389 eng info:eu-repo/semantics/altIdentifier/doi/10.18632/oncotarget.7588 info:eu-repo/semantics/altIdentifier/pmid/26918452 Oncotarget. - 2016 TGF-β biomarker glioblastoma integrin pSmad Adult Aged Aged, 80 and over Biomarkers, Tumor Cohort Studies Female Follow-Up Studies Gene Expression Regulation, Neoplastic Glioblastoma Humans Integrin alphaVbeta3 Male Middle Aged Neoplasm Staging Prognosis Receptors, Vitronectin Smad2 Protein Snake Venoms Survival Rate Young Adult Cilengitide in newly diagnosed glioblastoma: biomarker expression and outcome. http://purl.org/coar/resource_type/c_6501