Reinders J Wulff BB Mirouze M Marí-Ordóñez A Dapp M Rozhon W Bucher E Theiler G Paszkowski J 2009 Transgenerational epigenetic inheritance has been defined by the study of relatively few loci. We examined a population of recombinant inbred lines with epigenetically mosaic chromosomes consisting of wild-type and CG methylation-depleted segments (epiRILs). Surprisingly, transposons that were immobile in the parental lines displayed stochastic movement in 28% of the epiRILs. Although analysis after eight generations of inbreeding, supported by genome-wide DNA methylation profiling, identified recombined parental chromosomal segments, these were interspersed with unexpectedly high frequencies of nonparental methylation polymorphism. Hence, epigenetic inheritance in hybrids derived from parents with divergent epigenomes permits long-lasting epi-allelic interactions that violate Mendelian expectations. Such persistently "unstable" epigenetic states complicate linkage-based epigenomic mapping. Thus, future epigenomic analyses should consider possible genetic instabilities and alternative mapping strategies. application/pdf https://sonar.ch/global/documents/21220 eng info:eu-repo/semantics/altIdentifier/doi/10.1101/gad.524609 info:eu-repo/semantics/altIdentifier/pmid/19390088 info:eu-repo/semantics/openAccess Genes & development. - 2009 Arabidopsis Arabidopsis Proteins Chromosome Mapping Chromosomes, Plant DNA (Cytosine-5-)-Methyltransferases DNA Methylation DNA Transposable Elements Epigenesis, Genetic Genes, Plant Genome, Plant Genomic Instability Inbreeding Mosaicism Phenotype Recombination, Genetic Compromised stability of DNA methylation and transposon immobilization in mosaic Arabidopsis epigenomes. http://purl.org/coar/resource_type/c_6501