Nietlispach F Webb JG Ye J Cheung A Lichtenstein SV Carere RG Gurvitch R Thompson CR Ostry AJ Matzke L Allard MF 2012 OBJECTIVES This study sought to report on the pathology of transcatheter aortic valves explanted at early and late time points after transcatheter aortic valve implantation. BACKGROUND Information on pathological findings following transcatheter aortic valve implantation is scarce, particularly late after transcatheter aortic valve implantation. METHODS This study included 20 patients (13 men, median age 80 years [interquartile range: 72 to 84] years) with previous transcatheter aortic valve implantation with a valve explanted at autopsy (n = 17) or surgery (n = 3) up to 30 months after implantation (10 transapical and 10 transfemoral procedures). RESULTS Structural valve degeneration was not seen, although fibrous tissue ingrowth was observed at later time points with minimal effects on cusp mobility in 1 case. Minor alterations in valve configuration or placement were observed in up to 50% of cases, but they were not accompanied by substantial changes in valve function or reliably associated with chest compressions. Vascular or myocardial injury was common, especially within 30 days of transcatheter aortic valve implantation (about 69%), with the latter associated with left coronary ostial occlusion by calcified native aortic valve tissue in 2 cases. Mild to severe myocardial amyloidosis was present in nearly 33% of cases and likely played a role in the poor outcome of 3 patients. Endocarditis, migration of the valve, and embolization during the procedure led to surgical valve removal. CONCLUSIONS Structural degeneration was not seen and minor alterations of valve configuration or placement did not affect valve function and were not reliably caused by chest compressions. Vascular or myocardial injury is very common early after transcatheter aortic valve implantation and myocardial amyloidosis represents a relatively frequent potentially significant comorbid condition. https://sonar.ch/global/documents/219135 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcin.2012.03.012 info:eu-repo/semantics/altIdentifier/pmid/22625199 JACC. Cardiovascular interventions. - 2012 Aged Aged, 80 and over Amyloidosis Aortic Valve Aortic Valve Stenosis Autopsy British Columbia Cardiac Catheterization Cardiomyopathies Cardiovascular Diseases Cause of Death Device Removal Endocarditis Female Foreign-Body Migration Heart Valve Prosthesis Implantation Humans Male Middle Aged Myocardium Time Factors Treatment Outcome Pathology of transcatheter valve therapy. http://purl.org/coar/resource_type/c_6501