Da Cruz S Parone PA Gonzalo P Bienvenut WV Tondera D Jourdain A Quadroni M Martinou JC 2008 Stomatin is a member of a large family of proteins including prohibitins, HflK/C, flotillins, mechanoreceptors and plant defense proteins, that are thought to play a role in protein turnover. Using different proteomic approaches, we and others have identified SLP-2, a member of the stomatin gene family, as a component of the mitochondria. In this study, we show that SLP-2 is strongly associated with the mitochondrial inner membrane and that it interacts with prohibitins. Depleting HeLa cells of SLP-2 lead to increased proteolysis of prohibitins and of subunits of the respiratory chain complexes I and IV. Further supporting the role of SLP-2 in regulating the stability of specific mitochondrial proteins, we found that SLP-2 is up-regulated under conditions of mitochondrial stress leading to increased protein turnover. These data indicate that SLP-2 plays a role in regulating the stability of mitochondrial proteins including prohibitins and subunits of respiratory chain complexes. application/pdf https://sonar.ch/global/documents/220138 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbamcr.2008.02.006 info:eu-repo/semantics/altIdentifier/pmid/18339324 info:eu-repo/semantics/openAccess Biochimica et biophysica acta. - 2008 Animals Blood Proteins Cells, Cultured Electron Transport Complex I Electron Transport Complex IV HeLa Cells Humans Immunoprecipitation Membrane Proteins Mitochondria Mitochondrial Membranes Mitochondrial Proteins Repressor Proteins SLP-2 interacts with prohibitins in the mitochondrial inner membrane and contributes to their stability. http://purl.org/coar/resource_type/c_6501