Thom JT Oxenius A 2016 Herpesviruses establish life-long infection in their hosts and maintain latent reservoirs for sporadic reactivation at peripheral sites, such as skin and mucosae. For herpes simplex virus infection, experimental studies in mice revealed that immediate protection against local reactivation or superinfection events in the skin relies on tissue resident memory T cells (TRM) rather than on their circulating counterparts. Recent evidence extends this notion to cytomegalovirus infection, which potently induces TRM cells in both mice and humans particularly in mucosal tissues that constitute important viral sanctuaries and are relevant entry sites for challenge and superinfections. The discovery unravels promising opportunities to exploit cytomegalovirus based vaccine vectors for the specific induction of tissue resident T cell subsets. application/pdf https://sonar.ch/global/documents/223291 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.coviro.2016.01.014 info:eu-repo/semantics/altIdentifier/pmid/26855038 info:eu-repo/semantics/openAccess Current opinion in virology. - 2016 Animals Cytomegalovirus Cytomegalovirus Infections Host-Pathogen Interactions Humans Immunologic Memory Mucous Membrane Organ Specificity Phenotype T-Lymphocyte Subsets Viral Vaccines Virus Activation Virus Replication Tissue-resident memory T cells in cytomegalovirus infection. http://purl.org/coar/resource_type/c_6501