<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Gardinier MV</dc:creator>
  <dc:creator>Amiguet P</dc:creator>
  <dc:creator>Linington C</dc:creator>
  <dc:creator>Matthieu JM</dc:creator>
  <dc:date>1992</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Myelin/oligodendrocyte glycoprotein (MOG) is a primary target autoantigen in experimental autoimmune encephalomyelitis, a widely used animal model for autoimmune demyelinating diseases such as multiple sclerosis. We have isolated several rat MOG cDNAs and confirmed their identity by comparison with MOG N-terminal peptide sequence. As expected, MOG mRNA expression is CNS-specific and peaks during active myelination. Our studies show that full length MOG mRNA is approximately 1.6 kb and encodes a signal peptide of 27 amino acids, followed by 218 residues for mature MOG (24,962 MW). A single site for N-glycosylation is found at Asn-31. Rather than the ubiquitous AAUAAA polyadenylation signal, a series of three overlapping, rare poly A signals were identified. The N-terminal half of mature MOG shares 52% identity with bovine butyrophilin, a possible lipid receptor. This same region has 39% identity with chicken B-G antigen, a major histocompatibility complex antigen involved in B cell selection and immune repertoire development. We show that both MOG and butyrophilin, each exhibiting a single Ig-like variable region domain, meet criteria for inclusion in the immunoglobulin superfamily. Moreover, MOG appears to represent a unique member of this superfamily in that it possesses two potential transmembrane domains, in contrast to a single membrane-spanning domain or glycophospholipid anchor found in all other members of Ig superfamily members.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/2252</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1002/jnr.490330123</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/1453482</dc:relation>
  <dc:source>Journal of neuroscience research. - 1992</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Base Sequence</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Blotting, Northern</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Cloning, Molecular</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">DNA</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Genomic Library</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Immunoglobulins</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Membrane Glycoproteins</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Molecular Sequence Data</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Myelin Proteins</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Myelin-Associated Glycoprotein</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Myelin-Oligodendrocyte Glycoprotein</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Nucleic Acid Conformation</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">RNA, Messenger</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">Rats</dc:subject>
  <dc:title xmlns:ns16="xml" ns16:lang="en">Myelin/oligodendrocyte glycoprotein is a unique member of the immunoglobulin superfamily.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>