Semik E Gurgul A Ząbek T Ropka-Molik K Koch C Mählmann K Bugno-Poniewierska M 2017 Equine sarcoids are the most commonly detected skin tumours in Equidae. In the present research, a comparative transcriptomic analysis was performed which aimed at looking inside a tumour biology and identification of the expression profile as a potential source of cancer specific genes useful as biomarkers. We have used Horse Gene Expression Microarray data from matched equine sarcoids and tumour-distant skin samples. In total, 901 significantly differentially expressed genes (DEGs) between lesional and healthy skin samples have been identified (fold change ≥ 2; P < 0.05). The large subset of DEGs, with decreased expression, was associated with a suppression of malignant transformation, whereas several overexpressed genes were involved in the processes associated with growth and progression of a tumour or immune system activity. Our results, as a first to date, showed comprehensive transcriptome analysis of skin tumour in horses and pinpointed significant pathways and genes related with oncogenesis processes. https://sonar.ch/global/documents/22673 eng info:eu-repo/semantics/altIdentifier/doi/10.1111/vco.12279 info:eu-repo/semantics/altIdentifier/pmid/27779365 Veterinary and comparative oncology. - 2017 differentially expressed genes equine sarcoids gene expression microarray tumorigenesis Animals Biomarkers Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Ontology Horse Diseases Horses Oligonucleotide Array Sequence Analysis Real-Time Polymerase Chain Reaction Skin Neoplasms Transcriptome analysis of equine sarcoids. http://purl.org/coar/resource_type/c_6501