Haberman ID Lang PZ Broncano AF Kim SW Hafezi F Randleman JB 2018 PURPOSE To evaluate changes in regional corneal epithelial thickness after corneal crosslinking (CXL) using higher fluence (7.2 J/cm2) and accelerated treatment time (4 minutes) in eyes with progressive keratoconus using spectral-domain optical coherence tomography (SD-OCT) and to correlate focal epithelial and focal anterior curvature changes. SETTING Academic medical center in the United States. DESIGN Prospective case series. METHODS Patients had anterior segment SD-OCT (RTVue-100) with focal stromal and epithelial measurements and Scheimpflug imaging before and 1, 3, 6, and 12 months after accelerated CXL. RESULTS Twenty-seven eyes from 20 patients were evaluated. Before the accelerated CXL, the epithelium was thinnest in the inferior inner and outer temporal regions, whereas at 12 months postoperatively, the epithelium was significantly thinned in multiple inferior and nasal regions by 1.1 to 3.2 μm (P < .05, all measurements), with no significant changes from 6 to 12 months. Epithelial thickness standard deviation across the central 6.0 mm was significantly reduced by 3 months (1.4 μm, P = .09) and remained stable at 12 months (P = .009). Change in epithelial thickness was poorly correlated to change in anterior curvature (r = -0.035). CONCLUSIONS Significant epithelial remodeling occurred after accelerated CXL in eyes with progressive keratoconus, with improved regularity across the central 6.0 mm, by 6 months after treatment. There was poor correlation between focal epithelial thickness and anterior curvature changes, with wide variability between patients. Establishing the pattern of epithelial remodeling after CXL might help optimize future custom treatment protocols. https://sonar.ch/global/documents/232696 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcrs.2017.12.021 info:eu-repo/semantics/altIdentifier/pmid/29610026 Journal of cataract and refractive surgery. - 2018 Adolescent Adult Collagen Corneal Pachymetry Corneal Stroma Cross-Linking Reagents Epithelium, Corneal Female Humans Keratoconus Male Middle Aged Photochemotherapy Photosensitizing Agents Prospective Studies Riboflavin Time Factors Tomography, Optical Coherence Ultraviolet Rays Visual Acuity Young Adult Epithelial remodeling after corneal crosslinking using higher fluence and accelerated treatment time. http://purl.org/coar/resource_type/c_6501