<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Tersalvi, G</dc:creator>
  <dc:creator>Biasco, L</dc:creator>
  <dc:creator>Radovanovic, D</dc:creator>
  <dc:creator>Rickli, H</dc:creator>
  <dc:creator>Roffi, M</dc:creator>
  <dc:creator>Eberli, F</dc:creator>
  <dc:creator>Moccetti, M</dc:creator>
  <dc:creator>Jeger, R</dc:creator>
  <dc:creator>Moccetti, T</dc:creator>
  <dc:creator>Erne, P</dc:creator>
  <dc:creator>Pedrazzini, G.B</dc:creator>
  <dc:date>2020</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">&lt;jats:title&gt;Abstract&lt;/jats:title&gt;
               &lt;jats:sec&gt;
                  &lt;jats:title&gt;Introduction&lt;/jats:title&gt;
                  &lt;jats:p&gt;The association between alcohol consumption and the occurrence of coronary heart disease is well described in literature. Data regarding the impact of regular alcohol consumption on in-hospital outcomes in the setting of acute coronary syndrome (ACS) are lacking.&lt;/jats:p&gt;
               &lt;/jats:sec&gt;
               &lt;jats:sec&gt;
                  &lt;jats:title&gt;Purpose&lt;/jats:title&gt;
                  &lt;jats:p&gt;We aimed to evaluate the impact of self-reported alcohol consumption on in-hospital outcomes in patients with ACS.&lt;/jats:p&gt;
               &lt;/jats:sec&gt;
               &lt;jats:sec&gt;
                  &lt;jats:title&gt;Methods&lt;/jats:title&gt;
                  &lt;jats:p&gt;Data derived from patients enrolled between 2007 and 2019 in the Acute Myocardial Infarction in Switzerland (AMIS) Plus registry were retrospectively analyzed. The primary endpoint was all-cause in-hospital mortality, while secondary endpoints were set as incidence of major adverse cardiac and cerebrovascular events (MACCEs). Outcomes comparisons according to quantity of daily alcohol intake were also performed.&lt;/jats:p&gt;
               &lt;/jats:sec&gt;
               &lt;jats:sec&gt;
                  &lt;jats:title&gt;Results&lt;/jats:title&gt;
                  &lt;jats:p&gt;Records concerning alcohol consumption were available in 25707 patients; 5298 of them (21%) fulfilled the criteria of regular alcohol consumption. Daily alcohol intake was reported in 4059 (77%), of these patients (regular drinkers) with 2640 light drinkers (≤2 drinks/day) and 1419 heavy drinkers (&amp;amp;gt;2 drinks/day). Regular drinkers were predominantly male, younger, smokers, more comorbid and with a worse clinical presentation as compared to abstainers/occasional drinkers.&lt;/jats:p&gt;
                  &lt;jats:p&gt;In-hospital mortality and MACCEs of heavy drinkers were significantly higher compared to light drinkers (5.4% vs. 3.3% and 7.0% vs. 4.4%, both p=0.001). When tested together with GRACE risk score parameters, heavy alcohol consumption was independently associated to in-hospital mortality (p=0.004).&lt;/jats:p&gt;
               &lt;/jats:sec&gt;
               &lt;jats:sec&gt;
                  &lt;jats:title&gt;Conclusions&lt;/jats:title&gt;
                  &lt;jats:p&gt;Heavy alcohol consumption is an additional independent predictor of in-hospital mortality in patients presenting with ACS.&lt;/jats:p&gt;
                  &lt;jats:p&gt;Figure 1. Study flowchart.&lt;/jats:p&gt;
               &lt;/jats:sec&gt;
               &lt;jats:sec&gt;
                  &lt;jats:title&gt;Funding Acknowledgement&lt;/jats:title&gt;
                  &lt;jats:p&gt;Type of funding source: Other. Main funding source(s): Swiss Heart Foundation&lt;/jats:p&gt;
               &lt;/jats:sec&gt;</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/235776</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1093/ehjci/ehaa946.1597</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/issn/0195-668X</dc:relation>
  <dc:source>European Heart Journal. - Oxford University Press (OUP). - 2020, vol. 41, no. Supplement_2</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Cardiology and Cardiovascular Medicine</dc:subject>
  <dc:title xmlns:ns2="xml" ns2:lang="en">Heavy drinking habits are associated with worse in-hospital outcomes in patients with acute coronary syndrome</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>