Goncalves MD Lu C Tutnauer J Hartman TE Hwang SK Murphy CJ Pauli C Morris R Taylor S Bosch K Yang S Wang Y Van Riper J Lekaye HC Roper J Kim Y Chen Q Gross SS Rhee KY Cantley LC Yun J 2019 Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated with obesity and with an increased risk of colorectal cancer. Whether HFCS contributes directly to tumorigenesis is unclear. We investigated the effects of daily oral administration of HFCS in adenomatous polyposis coli (APC) mutant mice, which are predisposed to develop intestinal tumors. The HFCS-treated mice showed a substantial increase in tumor size and tumor grade in the absence of obesity and metabolic syndrome. HFCS increased the concentrations of fructose and glucose in the intestinal lumen and serum, respectively, and the tumors transported both sugars. Within the tumors, fructose was converted to fructose-1-phosphate, leading to activation of glycolysis and increased synthesis of fatty acids that support tumor growth. These mouse studies support the hypothesis that the combination of dietary glucose and fructose, even at a moderate dose, can enhance tumorigenesis. application/pdf https://sonar.ch/global/documents/235848 eng info:eu-repo/semantics/altIdentifier/doi/10.1126/science.aat8515 info:eu-repo/semantics/altIdentifier/pmid/30898933 info:eu-repo/semantics/openAccess Science (New York, N.Y.). - 2019 Adenomatous Polyposis Coli Protein Animals Carcinogenesis Diet High Fructose Corn Syrup Intestinal Neoplasms Mice Mice, Mutant Strains Neoplasm Grading Tumor Burden High-fructose corn syrup enhances intestinal tumor growth in mice. http://purl.org/coar/resource_type/c_6501