<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Hornemann T</dc:creator>
  <dc:date>2015</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Palmitoylation describes the enzymatic attachment of a 16-carbon atom fatty acid to a target protein. Such lipidation events occur in all eukaryotes and can be of reversible (S-palmitoylation) or irreversible (N-palmitoylation) nature. In particular S-palmitoylation is dynamically regulated by two opposing types of enzymes which add (palmitoyl acyltransferases - PAT) or remove (acyl protein thioesterases) palmitate from proteins. Protein palmitoylation is an important process that dynamically regulates the assembly and compartmentalization of many neuronal proteins at specific subcellular sites. Enzymes that regulate protein palmitoylation are critical for several biological processes. To date, eight palmitoylation related genes have been reported to be associated with human disease. This review intends to give an overview on the pathological changes which are associated with defects in the palmitoylation/depalmitoylation process.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/236503</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1007/s10545-014-9753-0</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/25091425</dc:relation>
  <dc:source>Journal of inherited metabolic disease. - 2015</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Acyltransferases</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Alzheimer Disease</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Carbon</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Focal Dermal Hypoplasia</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Huntington Disease</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Neuronal Ceroid-Lipofuscinoses</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Neurons</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Palmitic Acids</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Palmitoyl-CoA Hydrolase</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Schizophrenia</dc:subject>
  <dc:title xmlns:ns13="xml" ns13:lang="en">Palmitoylation and depalmitoylation defects.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>