Dall'Olio GM Vahdati AR Bertranpetit J Wagner A Laayouni H 2015 SUMMARY A wealth of large-scale genome sequencing projects opens the doors to new approaches to study the relationship between genotype and phenotype. One such opportunity is the possibility to apply genotype networks analysis to population genetics data. Genotype networks are a representation of the set of genotypes associated with a single phenotype, and they allow one to estimate properties such as the robustness of the phenotype to mutations, and the ability of its associated genotypes to evolve new adaptations. So far, though, genotype networks analysis has rarely been applied to population genetics data. To help fill this gap, here we present VCF2Networks, a tool to determine and study genotype network structure from single-nucleotide variant data. AVAILABILITY AND IMPLEMENTATION VCF2Networks is available at https://bitbucket.org/dalloliogm/vcf2networks. CONTACT giovanni.dallolio@kcl.ac.uk SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online. application/pdf https://sonar.ch/global/documents/236571 eng info:eu-repo/semantics/altIdentifier/doi/10.1093/bioinformatics/btu650 info:eu-repo/semantics/altIdentifier/pmid/25282646 info:eu-repo/semantics/openAccess Bioinformatics (Oxford, England). - 2015 Biological Evolution Gene Regulatory Networks Genetics, Population Genome, Human Genotype Humans Phenotype Polymorphism, Single Nucleotide Software VCF2Networks: applying genotype networks to single-nucleotide variants data. http://purl.org/coar/resource_type/c_6501