Berger-Bächi B 2002 The introduction and increasing use of antibiotics for antibacterial therapy has initiated a rapid development and expansion of antibiotic resistance in microorganisms, particularly in human pathogens. Additionally, a shift to an increase in number and severity of Gram-positive infections has been observed the last decades. Common to these pathogens is their tendency to accumulate multiple resistances under antibiotic pressure and selection. Methicillin-resistant Staphylococcus aureus (MRSA), that have acquired multiresistance to all classes of antibiotics, have become a serious nosocomial problem. Recently, the emergence of the first MRSA with reduced vancomycin susceptibility evoked the specter of a totally resistant S. aureus. Problems with multiresistance expand also to penicillin-resistant Streptococcus pneumoniae that are partially or totally resistant to multiple antibiotics, and to vancomycin-resistant Enterococcus ssp., completely resistant to all commonly used antibiotics. The rapid development of resistance is due to mutational events and/or gene transfer and acquisition of resistance determinants, allowing strains to survive antibiotic treatment. https://sonar.ch/global/documents/243749 eng info:eu-repo/semantics/altIdentifier/doi/10.1078/1438-4221-00185 info:eu-repo/semantics/altIdentifier/pmid/12139425 International journal of medical microbiology : IJMM. - 2002 Anti-Bacterial Agents Community-Acquired Infections Drug Resistance, Multiple, Bacterial Glycopeptides Gram-Positive Bacteria Gram-Positive Bacterial Infections Humans Methicillin Resistance Peptides Selection, Genetic Vancomycin Resistance Resistance mechanisms of gram-positive bacteria. http://purl.org/coar/resource_type/c_6501