<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Lehmann M</dc:creator>
  <dc:creator>Bousquet E</dc:creator>
  <dc:creator>Beydoun T</dc:creator>
  <dc:creator>Behar-Cohen F</dc:creator>
  <dc:date>2015</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">PURPOSE
Thick choroid (pachychoroid) is associated with central serous chorioretinopathy (CSC), but whether pachychoroid is inherited is unknown.


METHODS
In a prospective observational study, first- or second-degree relatives (16 individuals) of 5 patients with CSC had refraction and visual acuity measurement, fundus examination, nonmydriatic photography, and autofluorescence photography. Eyes were graded using the following criteria: 0: normal fundus and autofluorescence photography, 1: focal retinal pigment epithelium hyperfluorescence and/or hypofluorescence and/or retinal pigment epithelial detachment, 2: CSC or diffuse retinal epitheliopathy. Choroid thickness was measured by enhanced depth imaging mode on optical coherence tomography.


RESULTS
Considering 395 μm as the threshold limit for normal subfoveal choroidal thickness, 50% of the eyes from relatives had a thick choroid. Nine eyes of Grade 0 (28%) with an isolated pachychoroid would thus have been considered normal, if choroidal thickness was not included as a screening sign predisposing for CSC.


CONCLUSION
Our observation suggests that pachychoroid could be an inherited condition with potentially a dominant transmission mode. Its inclusion in the phenotype of CSC for genetic studies should be considered.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/246293</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1097/IAE.0000000000000287</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/25046398</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>Retina (Philadelphia, Pa.). - 2015</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Adolescent</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Adult</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Aged</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Central Serous Chorioretinopathy</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Choroid</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Choroid Diseases</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Female</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Fluorescein Angiography</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Genetic Diseases, Inborn</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Genetic Predisposition to Disease</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Male</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Middle Aged</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Prospective Studies</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">Retinal Pigment Epithelium</dc:subject>
  <dc:subject xmlns:ns16="xml" ns16:lang="en">Tomography, Optical Coherence</dc:subject>
  <dc:subject xmlns:ns17="xml" ns17:lang="en">Visual Acuity</dc:subject>
  <dc:title xmlns:ns18="xml" ns18:lang="en">PACHYCHOROID: an inherited condition?</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>