Mahmoud M Gobet N Cruz-Dávalos DI Mounier N Dessimoz C Sedlazeck FJ 2019 Recent research into structural variants (SVs) has established their importance to medicine and molecular biology, elucidating their role in various diseases, regulation of gene expression, ethnic diversity, and large-scale chromosome evolution-giving rise to the differences within populations and among species. Nevertheless, characterizing SVs and determining the optimal approach for a given experimental design remains a computational and scientific challenge. Multiple approaches have emerged to target various SV classes, zygosities, and size ranges. Here, we review these approaches with respect to their ability to infer SVs across the full spectrum of large, complex variations and present computational methods for each approach. https://sonar.ch/global/documents/246773 eng info:eu-repo/semantics/altIdentifier/doi/10.1186/s13059-019-1828-7 info:eu-repo/semantics/altIdentifier/pmid/31747936 Genome biology. - 2019 De novo assembly Gene fusion Hybrid Long-read Mapping RNA-Seq Short-read Structural variant (SV) detection Animals Genomic Structural Variation Genomics Humans Structural variant calling: the long and the short of it. http://purl.org/coar/resource_type/c_6501