<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Bleichert F</dc:creator>
  <dc:date>2019</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">The duplication of chromosomal DNA is a key cell cycle event that involves the controlled, bidirectional assembly of the replicative machinery. In a tightly regulated, multi-step reaction, replicative helicases and other components of the DNA synthesis apparatus are recruited to replication start sites. Although the molecular approaches for assembling this machinery vary between the different domains of life, a common theme revolves around the use of ATP-dependent initiation factors to recognize and remodel origins and to load replicative helicases in a bidirectional manner onto DNA. This review summarizes recent advances in understanding the mechanisms of replication initiation in eukaryotes, focusing on how the replicative helicase is loaded in this system.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/247065</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.sbi.2019.08.007</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/31630057</dc:relation>
  <dc:source>Current opinion in structural biology. - 2019</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Adenosine Triphosphate</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">DNA</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">DNA Helicases</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">DNA Replication</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">DNA-Directed DNA Polymerase</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Hydrolysis</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Models, Molecular</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Multienzyme Complexes</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Protein Binding</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Quantitative Structure-Activity Relationship</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Replication Origin</dc:subject>
  <dc:title xmlns:ns12="xml" ns12:lang="en">Mechanisms of replication origin licensing: a structural perspective.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>