Jenny C Biallas M Trajkovic I Fauchère JC Bucher HU Wolf M 2011 Early detection of cerebral hypoxemia is an important aim in neonatology. A relevant parameter to assess brain oxygenation may be the cerebral tissue oxygen saturation (StO(2)) measured by near-infrared spectroscopy (NIRS). So far the reproducibility of StO(2) measurements was too low for clinical application, probably due to inhomogeneities. The aim of this study was to test a novel sensor geometry which reduces the influence of inhomogeneities. Thirty clinically stable newborn infants, with a gestational age of median 33.9 (range 26.9 to 41.9) weeks, birth weight of 2220 (820 to 4230) g, postnatal age of 5 (1 to 71) days were studied. At least four StO(2) measurements of 1 min duration were carried out using NIRS on the lateral head. The sensor was repositioned between measurements. Reproducibility was calculated by a linear mixed effects model. The mean StO(2) was 79.99 ± 4.47% with a reproducibility of 2.76% and a between-infant variability of 4.20%. Thus, the error of measurement only accounts for 30.1% of the variability. The novel sensor geometry leads to considerably more precise measurements compared to previous studies with, e.g., ∼5% reproducibility for the NIRO 300. The novel StO(2) values hence have a higher clinical relevance. application/pdf https://sonar.ch/global/documents/251693 eng info:eu-repo/semantics/altIdentifier/doi/10.1117/1.3622756 info:eu-repo/semantics/altIdentifier/pmid/21950939 info:eu-repo/semantics/openAccess Journal of biomedical optics. - 2011 Algorithms Brain Brain Chemistry Female Humans Hypoxia, Brain Infant, Newborn Male Oximetry Oxygen Reproducibility of Results Spectroscopy, Near-Infrared Statistics, Nonparametric Reproducibility of cerebral tissue oxygen saturation measurements by near-infrared spectroscopy in newborn infants. http://purl.org/coar/resource_type/c_6501