Dresch C Leverrier Y Marvel J Shortman K 2012 Cross-presentation by dendritic cells (DCs) of exogenous antigens on MHC class I is important for the generation of immune responses to intracellular pathogens, as well as for maintenance of self tolerance. In mice, the CD8(+) DC lineage is specialised for this role. However, DCs of this lineage are not born with cross-presentation capacity. Several studies have demonstrated that it must be induced as a later developmental step by cytokines such as granulocyte macrophage colony-stimulating factor (GM-CSF), or by microbial products such as toll-like receptor (TLR) ligands. Increased cross-presentation capacity is thus induced in peripheral CD8 lineage DCs during inflammation or infection. However, this capacity is already fully developed in steady-state thymic CD8(+) DCs, in accordance with their role in the deletion of self-reactive developing T cells. https://sonar.ch/global/documents/255102 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.it.2012.04.009 info:eu-repo/semantics/altIdentifier/pmid/22677187 Trends in immunology. - 2012 Animals Antigens CD8-Positive T-Lymphocytes Cell Lineage Cross-Priming Dendritic Cells Humans Development of antigen cross-presentation capacity in dendritic cells. http://purl.org/coar/resource_type/c_6501