<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Clavel CM</dc:creator>
  <dc:creator>Păunescu E</dc:creator>
  <dc:creator>Nowak-Sliwinska P</dc:creator>
  <dc:creator>Griffioen AW</dc:creator>
  <dc:creator>Scopelliti R</dc:creator>
  <dc:creator>Dyson PJ</dc:creator>
  <dc:date>2015</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Following the identification of [Ru(η(6)-p-cymene)Cl2(1H,1H,2H,2H-perfluorodecyl-3-(pyridin-3-yl)propanoate)], a ruthenium(II)-arene complex with a perfluoroalkyl-modified ligand that displays remarkable in vitro cancer cell selectivity, a series of structurally related compounds were designed. In the new derivatives, the p-cymene ring and/or the chloride ligands are substituted by other ligands to modulate the steric bulk or aquation kinetics. The new compounds were evaluated in both in vitro (cytotoxicity and migration assays) and in vivo (chicken chorioallantoic membrane) models and were found to exhibit potent antivascular effects.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/256511</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1021/jm501655t</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/25812075</dc:relation>
  <dc:source>Journal of medicinal chemistry. - 2015</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Angiogenesis Inhibitors</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Antineoplastic Agents</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Cell Line, Tumor</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Cell Proliferation</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Chick Embryo</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Coordination Complexes</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Crystallography, X-Ray</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Cymenes</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Models, Molecular</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Monoterpenes</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Neoplasms</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Ruthenium</dc:subject>
  <dc:title xmlns:ns15="xml" ns15:lang="en">Modulating the Anticancer Activity of Ruthenium(II)-Arene Complexes.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>