Federau C Hagmann P Maeder P Müller M Meuli R Stuber M O'Brien K 2013 Measurement of microvascular perfusion with Intravoxel Incoherent Motion (IVIM) MRI is gaining interest. Yet, the physiological influences on the IVIM perfusion parameters ("pseudo-diffusion" coefficient D*, perfusion fraction f, and flow related parameter fD*) remain insufficiently characterized. In this article, we hypothesize that D* and fD*, which depend on blood speed, should vary during the cardiac cycle. We extended the IVIM model to include time dependence of D* = D*(t), and demonstrate in the healthy human brain that both parameters D* and fD* are significantly larger during systole than diastole, while the diffusion coefficient D and f do not vary significantly. The results non-invasively demonstrate the pulsatility of the brain's microvasculature. application/pdf https://sonar.ch/global/documents/257147 eng info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0072856 info:eu-repo/semantics/altIdentifier/pmid/24023649 info:eu-repo/semantics/openAccess PloS one. - 2013 Algorithms Anterior Cerebral Artery Brain Diastole Diffusion Magnetic Resonance Imaging Female Heart Humans Male Motion Perfusion Regional Blood Flow Systole Time Factors Young Adult Dependence of brain intravoxel incoherent motion perfusion parameters on the cardiac cycle. http://purl.org/coar/resource_type/c_6501