Huang HY Luther SA 2012 Interleukin-7 (IL-7) is known since many years as stromal-cell derived cytokine that plays a key role for the adaptive immune system. It promotes lymphocyte development in the bone marrow and thymus as well as naive and memory T cell homeostasis in the periphery. More recently, IL-7 reporter mice and other approaches have led to the further characterization of the various stromal cell sources of IL-7 in secondary lymphoid organs (SLO) and other tissues. We will review these advances along with a discussion of the regulation of IL-7 and its receptor, and compare the biological effects IL-7 has on adaptive as well as innate immune cells in SLO. Finally, we will review the role of IL-7 in development of SLO and tertiary lymphoid tissues that frequently are associated with sites of chronic inflammation. https://sonar.ch/global/documents/259171 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.smim.2012.02.008 info:eu-repo/semantics/altIdentifier/pmid/22444422 Seminars in immunology. - 2012 Animals Cell Lineage Homeostasis Humans Inflammation Interleukin-7 Lymphatic System Receptors, Interleukin-7 Expression and function of interleukin-7 in secondary and tertiary lymphoid organs. http://purl.org/coar/resource_type/c_6501