Joller N Kuchroo VK 2017 Co-inhibitory receptors play a key role in regulating T cell responses and maintaining immune homeostasis. Their inhibitory function prevents autoimmune responses but also restricts the ability of T cells to mount effective immune responses against tumors or persistent pathogens. T cells express a module of co-inhibitory receptors, which display great diversity in expression, structure, and function. Here, we focus on the co-inhibitory receptors Tim-3, Lag-3, and TIGIT and how they regulate T cell function, maintenance of self-tolerance, their role in regulating ongoing T cell responses at peripheral tissues, and their synergistic effects in regulating autoimmunity and antitumor responses. application/pdf https://sonar.ch/global/documents/259896 eng info:eu-repo/semantics/altIdentifier/doi/10.1007/82_2017_62 info:eu-repo/semantics/altIdentifier/pmid/28900677 info:eu-repo/semantics/openAccess Current topics in microbiology and immunology. - 2017 Animals Antigens, CD Autoimmunity Hepatitis A Virus Cellular Receptor 2 Humans Immune Tolerance Mice Neoplasms Receptors, Immunologic T-Lymphocytes Tim-3, Lag-3, and TIGIT. http://purl.org/coar/resource_type/c_6501