<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Oehl K</dc:creator>
  <dc:creator>Vrugt B</dc:creator>
  <dc:creator>Opitz I</dc:creator>
  <dc:creator>Meerang M</dc:creator>
  <dc:date>2018</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Despite advances in malignant pleural mesothelioma therapy, life expectancy of affected patients remains short. The limited efficiency of treatment options is mainly caused by inter- and intra-tumor heterogeneity of mesotheliomas. This diversity can be observed at the morphological and molecular levels. Molecular analyses reveal a high heterogeneity (i) between patients; (ii) within different areas of a given tumor in terms of different clonal compositions; and (iii) during treatment over time. The aim of the present review is to highlight this diversity and its therapeutic implications.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/259901</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms19061603</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/29848954</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>International journal of molecular sciences. - 2018</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">cancer stem cells</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">chemoresistance</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">inter-tumor heterogeneity</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">mesothelioma</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">spatial intra-tumor heterogeneity</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">targeted therapy</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">temporal intra-tumor heterogeneity</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Antineoplastic Agents</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Genetic Heterogeneity</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Lung Neoplasms</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Mesothelioma</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Neoplastic Stem Cells</dc:subject>
  <dc:title xmlns:ns14="xml" ns14:lang="en">Heterogeneity in Malignant Pleural Mesothelioma.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>