Baggiolini M Clark-Lewis I 1992 Interleukin-8 (IL-8) belongs to a family of small, structurally related cytokines similar to platelet factor 4. It is produced by phagocytes and mesenchymal cells exposed to inflammatory stimuli (e.g., interleukin-1 or tumor necrosis factor) and activates neutrophils inducing chemotaxis, exocytosis and the respiratory burst. In vivo, IL-8 elicits a massive neutrophil accumulation at the site of injection. Five neutrophil-activating cytokines similar to IL-8 in structure and function have been identified recently. IL-8 and the related cytokines are produced in several tissues upon infection, inflammation, ischemia, trauma etc., and are thought to be the main cause of local neutrophil accumulation. https://sonar.ch/global/documents/260340 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/0014-5793(92)80909-z info:eu-repo/semantics/altIdentifier/pmid/1639201 FEBS letters. - 1992 Amino Acid Sequence Animals Chemotaxis, Leukocyte Humans Inflammation Interleukin-8 Molecular Sequence Data Interleukin-8, a chemotactic and inflammatory cytokine. http://purl.org/coar/resource_type/c_6501