Inauen P Hunziker T Gerber H Bruckner-Tuderman L Braathen LR 1994 We report a 6-year-old boy suffering from acquired epidermolysis bullosa, who presented with extensive lesions of the mucous membranes and disseminated, herpetiform and 'cluster of jewels'-like vesicles and bullae arising on erythematous plaques. Direct immunofluorescence showed linear deposits of IgG and C3 at the epidermal basement membrane zone. Indirect immunofluorescence demonstrated circulating autoantibodies (titre 1:128-1:256) directed at the blister floor of human NaCl-split skin, and reacting specifically with collagen VII of the anchoring fibrils, as demonstrated by immunoblotting. The disease was controlled with a combination of dapsone and prednisone. This case demonstrates the importance of modern immunological techniques in classifying childhood autoimmune bullous diseases, as precise diagnosis is important in determining an appropriate therapeutic regimen. https://sonar.ch/global/documents/260421 eng info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2133.1994.tb08598.x info:eu-repo/semantics/altIdentifier/pmid/7857848 The British journal of dermatology. - 1994 Autoantibodies Basement Membrane Child Dapsone Drug Therapy, Combination Epidermolysis Bullosa Acquisita Fluorescent Antibody Technique Humans Immunoglobulin G Male Mouth Mucosa Mucous Membrane Prednisolone Childhood epidermolysis bullosa acquisita. http://purl.org/coar/resource_type/c_6501