<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Leib SL</dc:creator>
  <dc:creator>Täuber MG</dc:creator>
  <dc:date>1999</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Bacterial meningitis is fatal in 5% to 40% of patients and causes neurologic sequelae in up to 30% of survivors. Much has been learned recently about the mechanisms that lead to brain injury during meningitis. Once bacteria have gained access to the central nervous system, their multiplication triggers a complex host response consisting of humoral and cellular immune mediators, reactive oxygen intermediates, matrix-metalloproteinases, and other host-derived factors. Alterations of the cerebral vasculature, with disruption of the blood brain barrier and global and focal ischemia, ultimately lead to functional and structural brain damage. This article reviews current concepts of the pathophysiology of bacterial meningitis and emphasizes possible therapeutic strategies to prevent its harmful consequences.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/260529</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/s0891-5520(05)70093-3</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/10470554</dc:relation>
  <dc:source>Infectious disease clinics of North America. - 1999</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Blood-Brain Barrier</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Cerebral Ventricles</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Cerebrovascular Circulation</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Cytokines</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Excitatory Amino Acids</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Immunity, Cellular</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Intracranial Pressure</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Meninges</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Meningitis, Bacterial</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Metalloendopeptidases</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Neutrophils</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Nitric Oxide</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">Reactive Oxygen Species</dc:subject>
  <dc:subject xmlns:ns16="xml" ns16:lang="en">Subarachnoid Space</dc:subject>
  <dc:title xmlns:ns17="xml" ns17:lang="en">Pathogenesis of bacterial meningitis.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>