<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Palmiere C</dc:creator>
  <dc:creator>de Froidmont S</dc:creator>
  <dc:creator>Mangin P</dc:creator>
  <dc:creator>Werner D</dc:creator>
  <dc:creator>Lobrinus JA</dc:creator>
  <dc:date>2014</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">We herein report an autopsy case involving a 27-year-old Caucasian woman suffering from chronic adrenocortical insufficiency with a background of a polyendocrine disorder. Postmortem biochemistry revealed pathologically decreased aldosterone, cortisol, and dehydroepiandrosterone levels in postmortem serum from femoral blood as well as decreased cortisol and 17-hydroxycorticosteroid in urine. Decreased vitreous sodium and increased 3-beta-hydroxybutyrate and C-reactive protein concentrations were observed. The cause of death was determined to be acute adrenocortical insufficiency. Fasting ketoacidosis was postulated to have precipitated the Addisonian crisis. Traumatic causes of death and third-party involvement were excluded. The case highlights the importance of systematically performing exhaustive postmortem biochemical investigations to formulate appropriate hypothesis regarding the pathophysiological mechanisms involved in the death process.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/261311</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1111/1556-4029.12446</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/24673726</dc:relation>
  <dc:source>Journal of forensic sciences. - 2014</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Addisonian crisis</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">adrenocortical insufficiency</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">fasting</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">forensic sciences</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">ketoacidosis</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">postmortem biochemistry</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">17-Hydroxycorticosteroids</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">3-Hydroxybutyric Acid</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Addison Disease</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Adult</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Aldosterone</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">C-Reactive Protein</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Dehydroepiandrosterone</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Fasting</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">Female</dc:subject>
  <dc:subject xmlns:ns16="xml" ns16:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns17="xml" ns17:lang="en">Hydrocortisone</dc:subject>
  <dc:subject xmlns:ns18="xml" ns18:lang="en">Ketosis</dc:subject>
  <dc:subject xmlns:ns19="xml" ns19:lang="en">Sodium</dc:subject>
  <dc:subject xmlns:ns20="xml" ns20:lang="en">Vitreous Body</dc:subject>
  <dc:title xmlns:ns21="xml" ns21:lang="en">Ketoacidosis and adrenocortical insufficiency.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>