Mišic B Betzel RF Griffa A de Reus MA He Y Zuo XN van den Heuvel MP Hagmann P Sporns O Zatorre RJ 2018 Converging evidence from activation, connectivity, and stimulation studies suggests that auditory brain networks are lateralized. Here we show that these findings can be at least partly explained by the asymmetric network embedding of the primary auditory cortices. Using diffusion-weighted imaging in 3 independent datasets, we investigate the propensity for left and right auditory cortex to communicate with other brain areas by quantifying the centrality of the auditory network across a spectrum of communication mechanisms, from shortest path communication to diffusive spreading. Across all datasets, we find that the right auditory cortex is better integrated in the connectome, facilitating more efficient communication with other areas, with much of the asymmetry driven by differences in communication pathways to the opposite hemisphere. Critically, the primacy of the right auditory cortex emerges only when communication is conceptualized as a diffusive process, taking advantage of more than just the topologically shortest paths in the network. Altogether, these results highlight how the network configuration and embedding of a particular region may contribute to its functional lateralization. application/pdf https://sonar.ch/global/documents/261857 eng info:eu-repo/semantics/altIdentifier/doi/10.1093/cercor/bhy101 info:eu-repo/semantics/altIdentifier/pmid/29722805 info:eu-repo/semantics/openAccess Cerebral cortex (New York, N.Y. : 1991). - 2018 Acoustic Stimulation Adult Aged Auditory Cortex Auditory Pathways Cohort Studies Communication Connectome Diffusion Magnetic Resonance Imaging Female Functional Laterality Humans Image Processing, Computer-Assisted Male Middle Aged Young Adult Network-Based Asymmetry of the Human Auditory System. http://purl.org/coar/resource_type/c_6501