Heinemann M Zenobi R 2011 Recent discoveries suggest that cells of a clonal population often display multiple metabolic phenotypes at the same time. Motivated by the success of mass spectrometry (MS) in the investigation of population-level metabolomics, the analytical community has initiated efforts towards MS-based single cell metabolomics to investigate metabolic phenomena that are buried under the population average. Here, we review the current approaches and illustrate their advantages and disadvantages. Because of significant advances in the field, different technologies are now at the verge of generating data that are useful for exploring and investigating metabolic heterogeneity. application/pdf https://sonar.ch/global/documents/265449 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.copbio.2010.09.008 info:eu-repo/semantics/altIdentifier/pmid/20934866 info:eu-repo/semantics/openAccess Current opinion in biotechnology. - 2011 Animals Metabolomics Microfluidic Analytical Techniques Phenotype Single-Cell Analysis Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Single cell metabolomics. http://purl.org/coar/resource_type/c_6501