<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Federau C</dc:creator>
  <dc:creator>Meuli R</dc:creator>
  <dc:creator>O'Brien K</dc:creator>
  <dc:creator>Maeder P</dc:creator>
  <dc:creator>Hagmann P</dc:creator>
  <dc:date>2014</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">BACKGROUND AND PURPOSE
Intravoxel incoherent motion MRI has been proposed as an alternative method to measure brain perfusion. Our aim was to evaluate the utility of intravoxel incoherent motion perfusion parameters (the perfusion fraction, the pseudodiffusion coefficient, and the flow-related parameter) to differentiate high- and low-grade brain gliomas.


MATERIALS AND METHODS
The intravoxel incoherent motion perfusion parameters were assessed in 21 brain gliomas (16 high-grade, 5 low-grade). Images were acquired by using a Stejskal-Tanner diffusion pulse sequence, with 16 values of b (0-900 s/mm(2)) in 3 orthogonal directions on 3T systems equipped with 32 multichannel receiver head coils. The intravoxel incoherent motion perfusion parameters were derived by fitting the intravoxel incoherent motion biexponential model. Regions of interest were drawn in regions of maximum intravoxel incoherent motion perfusion fraction and contralateral control regions. Statistical significance was assessed by using the Student t test. In addition, regions of interest were drawn around all whole tumors and were evaluated with the help of histograms.


RESULTS
In the regions of maximum perfusion fraction, perfusion fraction was significantly higher in the high-grade group (0.127 ± 0.031) than in the low-grade group (0.084 ± 0.016, P &lt; .001) and in the contralateral control region (0.061 ± 0.011, P &lt; .001). No statistically significant difference was observed for the pseudodiffusion coefficient. The perfusion fraction correlated moderately with dynamic susceptibility contrast relative CBV (r = 0.59). The histograms of the perfusion fraction showed a "heavy-tailed" distribution for high-grade but not low-grade gliomas.


CONCLUSIONS
The intravoxel incoherent motion perfusion fraction is helpful for differentiating high- from low-grade brain gliomas.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/266086</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.3174/ajnr.A3686</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/23928134</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>AJNR. American journal of neuroradiology. - 2014</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Adolescent</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Adult</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Aged</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Aged, 80 and over</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Algorithms</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Blood Flow Velocity</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Brain Neoplasms</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Cerebrovascular Circulation</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Child</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Child, Preschool</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Female</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Glioma</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Image Enhancement</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">Image Interpretation, Computer-Assisted</dc:subject>
  <dc:subject xmlns:ns16="xml" ns16:lang="en">Magnetic Resonance Angiography</dc:subject>
  <dc:subject xmlns:ns17="xml" ns17:lang="en">Male</dc:subject>
  <dc:subject xmlns:ns18="xml" ns18:lang="en">Middle Aged</dc:subject>
  <dc:subject xmlns:ns19="xml" ns19:lang="en">Motion</dc:subject>
  <dc:subject xmlns:ns20="xml" ns20:lang="en">Reproducibility of Results</dc:subject>
  <dc:subject xmlns:ns21="xml" ns21:lang="en">Sensitivity and Specificity</dc:subject>
  <dc:subject xmlns:ns22="xml" ns22:lang="en">Young Adult</dc:subject>
  <dc:title xmlns:ns23="xml" ns23:lang="en">Perfusion measurement in brain gliomas with intravoxel incoherent motion MRI.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>