<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Monje A</dc:creator>
  <dc:creator>Eick S</dc:creator>
  <dc:creator>Buser D</dc:creator>
  <dc:creator>Salvi GE</dc:creator>
  <dc:date>2020</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">OBJECTIVE
To evaluate microbial and host-derived biomarker changes during experimental peri-implantitis in the Beagle dog.


BACKGROUND
Limited data exist on the microbial and biomarker changes during progressive bone loss as result of experimental peri-implantitis.


METHODS
In total, 36 implants (ndogs  = 6) were assessed over 3 episodes of ligature-induced peri-implantitis followed by a period of spontaneous progression. Implants with hybrid (H) and completely rough (R) surface designs were used. Clinical and radiographic parameters were recorded at 4 timepoints. Peri-implant sulcus fluid was collected from the buccal and lingual aspects of the implants. The presence of 7 bacterial species and 2 host-derived biomarkers was assessed during the study period.


RESULTS
Total bacterial counts were significantly correlated with marginal bone loss (MBL) (r = .21; P = .009). Further, Phorphyromonas gulae (Pg) and Tannerella forsythia (Tf) were commonly correlated with MBL, suppuration (SUP) and the sulcular bleeding index scores (mSBI) (P &lt; .05). Other bacteria were further correlated with SUP, mSBI, and MBL. While the analyzed bacteria dropped, Prevotella intermedia (Pi) further increased during the spontaneous progressive phase (P &lt; .05). Total bacterial load did not differ significantly between H and R implants. Host-derived IL-10 was undetected along the study period. IL-1β positively correlated with probing pocket depth (r = .18; P = .03). During spontaneous progression, H implants displayed statistically significant lower levels of IL-1β (P = .003).


CONCLUSION
Experimental peri-implantitis is associated with an increase in bacterial counts. While Pg and Tf are associated with ligature-induced disease progression, Pi augmented its load during the spontaneous progressive phase. IL-1β is associated with pocket probing depth and influenced by implant surface characteristics during the spontaneous progression phase.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/270</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1111/jre.12797</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/32885473</dc:relation>
  <dc:source>Journal of periodontal research. - 2020</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">biomarker</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">dental implant</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">endosseous implant</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">fusobacterium nucleatum</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">peri-implantitis</dc:subject>
  <dc:title xmlns:ns6="xml" ns6:lang="en">Microbial and host-derived biomarker changes during ligature-induced and spontaneous peri-implantitis in the Beagle dog.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>