Maechler P 2017 Pancreatic beta-cells secrete insulin in response to circulating glucose, thereby maintaining euglycemia. Inside the beta-cell, glucose is transformed into intracellular signals stimulating exocytosis. While calcium is an obligatory messenger, this ion is not sufficient to promote the full secretory response. Accordingly, glucose metabolism produces the additive factor glutamate that participates to an amplifying pathway of the calcium signal. Although intracellular glutamate potentiates insulin secretion, extracellular glutamate may activate ionotropic receptors. As a consequence of such activation, insulin exocytosis is slowed down. Therefore, for the beta-cell glutamate is a double-edged sword, an amplifying pathway and a negative feedback, illustrating the principle of homeostasis. application/pdf https://sonar.ch/global/documents/271762 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.diabres.2017.07.009 info:eu-repo/semantics/altIdentifier/pmid/28743063 info:eu-repo/semantics/openAccess Diabetes research and clinical practice. - 2017 Glucose Glutamate Insulin Pancreatic beta-cell Animals Glucose Glutamic Acid Insulin Insulin Secretion Insulin-Secreting Cells Glutamate pathways of the beta-cell and the control of insulin secretion. http://purl.org/coar/resource_type/c_6501