Canales-Rodríguez EJ Legarreta JH Pizzolato M Rensonnet G Girard G Patino JR Barakovic M Romascano D Alemán-Gómez Y Radua J Pomarol-Clotet E Salvador R Thiran JP Daducci A 2019 Spherical deconvolution methods are widely used to estimate the brain's white-matter fiber orientations from diffusion MRI data. In this study, eight spherical deconvolution algorithms were implemented and evaluated. These included two model selection techniques based on the extended Bayesian information criterion (i.e., best subset selection and the least absolute shrinkage and selection operator), iteratively reweighted l2- and l1-norm approaches to approximate the l0-norm, sparse Bayesian learning, Cauchy deconvolution, and two accelerated Richardson-Lucy algorithms. Results from our exhaustive evaluation show that there is no single optimal method for all different fiber configurations, suggesting that further studies should be conducted to find the optimal way of combining solutions from different methods. We found l0-norm regularization algorithms to resolve more accurately fiber crossings with small inter-fiber angles. However, in voxels with very dominant fibers, algorithms promoting more sparsity are less accurate in detecting smaller fibers. In most cases, the best algorithm to reconstruct fiber crossings with two fibers did not perform optimally in voxels with one or three fibers. Therefore, simplified validation systems as employed in a number of previous studies, where only two fibers with similar volume fractions were tested, should be avoided as they provide incomplete information. Future studies proposing new reconstruction methods based on high angular resolution diffusion imaging data should validate their results by considering, at least, voxels with one, two, and three fibers, as well as voxels with dominant fibers and different diffusion anisotropies. application/pdf https://sonar.ch/global/documents/27639 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuroimage.2018.08.071 info:eu-repo/semantics/altIdentifier/pmid/30193974 info:eu-repo/semantics/openAccess NeuroImage. - 2019 Diffusion MRI LASSO Non-negative least squares Sparse regression Spherical deconvolution Algorithms Bayes Theorem Brain Diffusion Magnetic Resonance Imaging Diffusion Tensor Imaging Humans Image Processing, Computer-Assisted Reproducibility of Results Signal Processing, Computer-Assisted Surveys and Questionnaires White Matter Sparse wars: A survey and comparative study of spherical deconvolution algorithms for diffusion MRI. http://purl.org/coar/resource_type/c_6501