Locher KP 2016 ABC transporters catalyze transport reactions, such as the high-affinity uptake of micronutrients into bacteria and the export of cytotoxic compounds from mammalian cells. Crystal structures of ABC domains and full transporters have provided a framework for formulating reaction mechanisms of ATP-driven substrate transport, but recent studies have suggested remarkable mechanistic diversity within this protein family. This review evaluates the differing mechanistic proposals and outlines future directions for the exploration of ABC-transporter-catalyzed reactions. application/pdf https://sonar.ch/global/documents/277238 eng info:eu-repo/semantics/altIdentifier/doi/10.1038/nsmb.3216 info:eu-repo/semantics/altIdentifier/pmid/27273632 info:eu-repo/semantics/openAccess Nature structural & molecular biology. - 2016 ATP-Binding Cassette Transporters Adenosine Triphosphate Animals Bacteria Biological Transport Catalytic Domain Gene Expression Humans Hydrolysis Models, Molecular Protein Binding Protein Domains Protein Folding Protein Structure, Secondary Mechanistic diversity in ATP-binding cassette (ABC) transporters. http://purl.org/coar/resource_type/c_6501