Schneiter P Gillet M Chioléro R Jéquier E Tappy L 1999 Seven patients with liver cirrhosis and five healthy subjects were studied over 4 hours after ingestion of a glucose meal to determine whether alterations of hepatic nonoxidative glucose disposal participate in the pathogenesis of impaired glucose tolerance. Hepatic uridyl-diphosphoglucose (UDPG) turnover was calculated from the isotopic enrichment of urinary acetaminophen glucuronide during continuous infusion of 13C-galactose and used as an index of hepatic glycogen synthesis. Patients with cirrhosis had postprandial hyperglycemia and decreased glucose clearance, but hepatic UDPG turnover was not altered (1.84 +/- 0.29 mg/kg fat-free mass min v 1.76 +/- 0.15 in controls, nonsignificant). It is concluded that hepatic postprandial glycogen synthesis is unaltered in patients with advanced cirrhosis, demonstrating important hepatic functional reserve. https://sonar.ch/global/documents/277803 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/s0026-0495(99)90265-2 info:eu-repo/semantics/altIdentifier/pmid/10535388 Metabolism: clinical and experimental. - 1999 Adult Carbon Isotopes Eating Female Galactose Glucose Glucose Intolerance Humans Hyperglycemia Intestinal Absorption Liver Liver Cirrhosis Liver Glycogen Male Middle Aged Postprandial Period Prothrombin Time Reference Values Uridine Diphosphate Glucose Hepatic nonoxidative disposal of an oral glucose meal in patients with liver cirrhosis. http://purl.org/coar/resource_type/c_6501