<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Niggeler A</dc:creator>
  <dc:creator>Tetens J</dc:creator>
  <dc:creator>Stäuble A</dc:creator>
  <dc:creator>Steiner A</dc:creator>
  <dc:creator>Drögemüller C</dc:creator>
  <dc:date>2017</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Footrot is one of the most important causes of lameness in global sheep populations and is characterized by a bacterial infection of the interdigital skin. As a multifactorial disease, its clinical representation depends not only on pathogen factors and environmental components but also on the individual resistance/susceptibility of the host. A genetic component has been shown in previous studies; however, so far no causative genetic variant influencing the risk of developing footrot has been identified. In this study, we genotyped 373 Swiss White Alpine sheep, using the ovine high-density 600k SNP chip, in order to run a DNA-based comparison of individuals with known clinical footrot status. We performed a case-control genome-wide association study, which revealed a genome-wide significant association for SNP rs418747104 on ovine chromosome 2 at 81.2 Mb. The three best associated SNP markers were located at the MPDZ gene, which codes for the multiple PDZ domain crumbs cell polarity complex component protein, also known as multi-PDZ domain protein 1 (MUPP1). This protein is possibly involved in maintaining the barrier function and integrity of tight junctions. Therefore, we speculate that individuals carrying MPDZ variants may differ in their footrot resistance/susceptibility due to modified horn and interdigital skin integrity. In conclusion, our study reveals that MPDZ might represent a functional candidate gene, and further research is needed to explore its role in footrot affected sheep.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/277</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1111/age.12614</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/28983925</dc:relation>
  <dc:source>Animal genetics. - 2017</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">
Dichelobacter nodosus
</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">
GWAS
</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">
MPDZ
</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">MUPP1</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">lameness</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Carrier Proteins</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Disease Resistance</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Foot Rot</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Genetic Predisposition to Disease</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Genome-Wide Association Study</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Hoof and Claw</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Linear Models</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Models, Genetic</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">Polymorphism, Single Nucleotide</dc:subject>
  <dc:subject xmlns:ns16="xml" ns16:lang="en">Sheep</dc:subject>
  <dc:subject xmlns:ns17="xml" ns17:lang="en">Sheep Diseases</dc:subject>
  <dc:title xmlns:ns18="xml" ns18:lang="en">A genome-wide significant association on chromosome 2 for footrot resistance/susceptibility in Swiss White Alpine sheep.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>