<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Altaf M</dc:creator>
  <dc:creator>Stoeckli-Evans H</dc:creator>
  <dc:date>2017</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Tranexamic acid [systematic name: trans-4-(amino-meth-yl)cyclo-hexane-1-carb-oxy-lic acid], is an anti-fibrinolytic amino acid that exists as a zwitterion [trans-4-(ammonio-meth-yl)cyclo-hexane-1-carboxyl-ate] in the solid state. Its reaction with copper chloride leads to the formation of a compound with a copper(II) paddle-wheel structure that crystallizes as a hexa-hydrate, [Cu2Cl2(C8H15NO2)4]2+·2Cl-·6H2O. The asymmetric unit is composed of a copper(II) cation, two zwitterionic tranexamic acid units, a coordinating Cl- anion and a free Cl- anion, together with three water mol-ecules of crystallization. The whole structure is generated by inversion symmetry, with the Cu⋯Cu axle of the paddle-wheel dication being located about a center of symmetry. The cyclo-hexane rings of the zwitterionic tranexamic acid units have chair conformations. The carboxyl-ate groups that bridge the two copper(II) cations are inclined to one another by 88.4 (8)°. The copper(II) cation is ligated by four carboxyl-ate O atoms in the equatorial plane and by a Cl- ion in the axial position. Hence, it has a fivefold O4Cl coordination sphere with a perfect square-pyramidal geometry and a τ5 index of zero. In the crystal, the paddle-wheel dications are linked by a series of N-H⋯Cl hydrogen bonds, involving the coordinating and free Cl- ions, forming a three-dimensional network. This network is strengthened by a series of N-H⋯Owater, Owater-H⋯Cl and Owater-H⋯O hydrogen bonds.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/278200</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1107/S2056989017012543</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/29250350</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>Acta crystallographica. Section E, Crystallographic communications. - 2017</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">anti­fibrinolytic amino acid</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">copper(II)</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">crystal structure</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">fibrinolytic inhibitor</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">hydrogen bonding</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">paddle-wheel</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">tranexamic acid</dc:subject>
  <dc:title xmlns:ns8="xml" ns8:lang="en">A copper(II) paddle-wheel structure of tranexamic acid: di-chloro-tetra-kis-[μ-4-(ammonio-meth-yl)cyclo-hexane-1-carboxyl-ato-O,O']dicopper(II) dichloride hexa-hydrate.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>