<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Cogliatti SB</dc:creator>
  <dc:creator>Griesser H</dc:creator>
  <dc:creator>Peng H</dc:creator>
  <dc:creator>Du MQ</dc:creator>
  <dc:creator>Isaacson PG</dc:creator>
  <dc:creator>Zimmermann DR</dc:creator>
  <dc:creator>Maibach RC</dc:creator>
  <dc:creator>Schmid U</dc:creator>
  <dc:date>2000</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Fifty-five cases of primary extranodal high-grade B-cell non-Hodgkin's lymphoma were investigated for bcl-2 and p53 protein expression as well as for t(14;18) translocations and p53 mutations. Phenotypic and genotypic profiles were compared between tumours of gastric (27 cases) and non-gastric (28 cases) origin. bcl-2 protein expression was significantly lower in gastric (11/27) than in non-gastric (28/28) lymphomas (p&lt;0.0001), while nuclear p53 protein expression did not differ significantly between these two groups. In the stomach, there were no significant differences in either bcl-2 or p53 expression profiles between high-grade lymphomas with (n=14) and without (n=13) evidence of a low-grade component of MALT type. However, secondary high-grade lymphomas showed a significant down-regulation of bcl-2 protein (p&lt;0.0001) and, conversely, an up-regulation of p53 protein (p&lt;0.0001) as compared with their low-grade tumour components. In extranodal high-grade B-cell lymphomas, bcl-2 protein expression was not associated with t(14;18) translocation. Only one gastric lymphoma had a p53 point mutation with potential alteration of the amino acid sequence. These findings indicate that primary gastric high-grade B-cell lymphomas are immunohistologically distinct from primary extranodal high-grade B-cell lymphomas of an origin other than in the stomach.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/278233</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1002/1096-9896(2000)9999:9999&lt;::AID-PATH733&gt;3.0.CO;2-U</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/11113864</dc:relation>
  <dc:source>The Journal of pathology. - 2000</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Biomarkers, Tumor</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Chromosomes, Human, Pair 14</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Chromosomes, Human, Pair 18</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Gene Expression Regulation, Neoplastic</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Genes, p53</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Immunoenzyme Techniques</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Lymphoma, B-Cell</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Lymphoma, Non-Hodgkin</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Neoplasm Proteins</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Proto-Oncogene Proteins c-bcl-2</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Stomach Neoplasms</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Translocation, Genetic</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Tumor Suppressor Protein p53</dc:subject>
  <dc:title xmlns:ns15="xml" ns15:lang="en">Significantly different bcl-2 expression profiles in gastric and non-gastric primary extranodal high-grade B-cell lymphomas.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>