<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Gillessen S</dc:creator>
  <dc:creator>Gilson C</dc:creator>
  <dc:creator>James N</dc:creator>
  <dc:creator>Adler A</dc:creator>
  <dc:creator>Sydes MR</dc:creator>
  <dc:creator>Clarke N</dc:creator>
  <dc:date>2016</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Metformin is a safe, well-tolerated, inexpensive treatment that can be given in addition to current standard-of-care therapies for prostate cancer. Its use might mitigate the deleterious side effects of castration and exert an additional anticancer effect. It will be incorporated in the STAMPEDE trial platform in summer 2016. This will test its true utility as a repurposed treatment for men with high-risk locally advanced or metastatic prostate cancer at first presentation.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/278336</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.eururo.2016.07.015</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/27450106</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>European urology. - 2016</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Androgen Antagonists</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Drug Repositioning</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Drug Therapy, Combination</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Hyperglycemia</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Hypoglycemic Agents</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Male</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Metformin</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Neoplasm Metastasis</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Orchiectomy</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Prostatic Neoplasms</dc:subject>
  <dc:title xmlns:ns12="xml" ns12:lang="en">Repurposing Metformin as Therapy for Prostate Cancer within the STAMPEDE Trial Platform.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>