Morgan AR Touchard S Leckey C O'Hagan C Nevado-Holgado AJ Barkhof F Bertram L Blin O Bos I Dobricic V Engelborghs S Frisoni G Frölich L Gabel S Johannsen P Kettunen P Kłoszewska I Legido-Quigley C Lleó A Martinez-Lage P Mecocci P Meersmans K Molinuevo JL Peyratout G Popp J Richardson J Sala I Scheltens P Streffer J Soininen H Tainta-Cuezva M Teunissen C Tsolaki M Vandenberghe R Visser PJ Vos S Wahlund LO Wallin A Westwood S Zetterberg H Lovestone S Morgan BP 2019 INTRODUCTION Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a "Holy Grail" of AD research and intensively sought; however, there are no well-established plasma markers. METHODS A hypothesis-led plasma biomarker search was conducted in the context of international multicenter studies. The discovery phase measured 53 inflammatory proteins in elderly control (CTL; 259), mild cognitive impairment (MCI; 199), and AD (262) subjects from AddNeuroMed. RESULTS Ten analytes showed significant intergroup differences. Logistic regression identified five (FB, FH, sCR1, MCP-1, eotaxin-1) that, age/APOε4 adjusted, optimally differentiated AD and CTL (AUC: 0.79), and three (sCR1, MCP-1, eotaxin-1) that optimally differentiated AD and MCI (AUC: 0.74). These models replicated in an independent cohort (EMIF; AUC 0.81 and 0.67). Two analytes (FB, FH) plus age predicted MCI progression to AD (AUC: 0.71). DISCUSSION Plasma markers of inflammation and complement dysregulation support diagnosis and outcome prediction in AD and MCI. Further replication is needed before clinical translation. https://sonar.ch/global/documents/279594 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jalz.2019.03.007 info:eu-repo/semantics/altIdentifier/pmid/31047856 Alzheimer's & dementia : the journal of the Alzheimer's Association. - 2019 Alzheimer's disease Biomarker Complement Inflammation Plasma Aged Alzheimer Disease Amyloid beta-Peptides Biomarkers Cognitive Dysfunction Cohort Studies Complement Factor B Complement Factor H Humans Inflammation Internationality Prognosis Inflammatory biomarkers in Alzheimer's disease plasma. http://purl.org/coar/resource_type/c_6501