<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Mariotto A</dc:creator>
  <dc:creator>Pavlova O</dc:creator>
  <dc:creator>Park HS</dc:creator>
  <dc:creator>Huber M</dc:creator>
  <dc:creator>Hohl D</dc:creator>
  <dc:date>2016</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">The homeodomain-only protein homeobox (HOPX) is the smallest known member of the homeodomain-containing protein family, atypically unable to bind DNA. HOPX is widely expressed in diverse tissues, where it is critically involved in the regulation of proliferation and differentiation. In human skin, HOPX controls epidermal formation through the regulation of late differentiation markers, and HOPX expression correlates with the level of differentiation in cutaneous pathologies. In mouse skin, Hopx was additionally identified as a lineage tracing marker of quiescent hair follicle stem cells. This review discusses current knowledge of HOPX structure and function in normal and pathological conditions.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/281285</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jid.2016.01.032</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/27017330</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>The Journal of investigative dermatology. - 2016</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Cell Differentiation</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Cell Proliferation</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">DNA Methylation</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Gene Expression Regulation, Neoplastic</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Genes, Homeobox</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Homeodomain Proteins</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Mice</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Sensitivity and Specificity</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Skin Neoplasms</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Tumor Cells, Cultured</dc:subject>
  <dc:title xmlns:ns13="xml" ns13:lang="en">HOPX: The Unusual Homeodomain-Containing Protein.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>