Ciuffi A Mohammadi P Golumbeanu M di Iulio J Telenti A 2015 Despite effective treatment, HIV is not completely eliminated from the infected organism because of the existence of viral reservoirs. A major reservoir consists of infected resting CD4+ T cells, mostly of memory type, that persist over time due to the stable proviral insertion and a long cellular lifespan. Resting cells do not produce viral particles and are protected from viral-induced cytotoxicity or immune killing. However, these latently infected cells can be reactivated by stochastic events or by external stimuli. The present review focuses on novel genome-wide technologies applied to the study of integration, transcriptome, and proteome characteristics and their recent contribution to the understanding of HIV latency. application/pdf https://sonar.ch/global/documents/281337 eng info:eu-repo/semantics/altIdentifier/doi/10.1007/s11904-014-0240-x info:eu-repo/semantics/altIdentifier/pmid/25586146 info:eu-repo/semantics/openAccess Current HIV/AIDS reports. - 2015 Computational Biology HIV Humans Virus Latency Bioinformatics and HIV latency. http://purl.org/coar/resource_type/c_6501