Vijaykrishna D Holmes EC Joseph U Fourment M Su YC Halpin R Lee RT Deng YM Gunalan V Lin X Stockwell TB Fedorova NB Zhou B Spirason N Kühnert D Bošková V Stadler T Costa AM Dwyer DE Huang QS Jennings LC Rawlinson W Sullivan SG Hurt AC Maurer-Stroh S Wentworth DE Smith GJ Barr IG 2015 A complex interplay of viral, host, and ecological factors shapes the spatio-temporal incidence and evolution of human influenza viruses. Although considerable attention has been paid to influenza A viruses, a lack of equivalent data means that an integrated evolutionary and epidemiological framework has until now not been available for influenza B viruses, despite their significant disease burden. Through the analysis of over 900 full genomes from an epidemiological collection of more than 26,000 strains from Australia and New Zealand, we reveal fundamental differences in the phylodynamics of the two co-circulating lineages of influenza B virus (Victoria and Yamagata), showing that their individual dynamics are determined by a complex relationship between virus transmission, age of infection, and receptor binding preference. In sum, this work identifies new factors that are important determinants of influenza B evolution and epidemiology. https://sonar.ch/global/documents/286487 eng info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.05055 info:eu-repo/semantics/altIdentifier/pmid/25594904 eLife. - 2015 antigenic drift epidemiology evolution evolutionary biology genomics human infectious disease influenza virus microbiology viruses Age Distribution Animals Antigens, Viral Asparagine Dogs Evolution, Molecular Genetic Variation Genome, Viral Glycosylation Hemagglutinin Glycoproteins, Influenza Virus Humans Influenza A virus Influenza B virus Influenza, Human Madin Darby Canine Kidney Cells Models, Molecular New Zealand Phylogeny Reassortant Viruses Selection, Genetic Time Factors Victoria The contrasting phylodynamics of human influenza B viruses. http://purl.org/coar/resource_type/c_6501