<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Schmid C</dc:creator>
  <dc:date>1995</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">The insulin-like growth factors I and II are single chain polypeptides homologous to proinsulin. IGF I and IGF II contribute to cell regulation and stimulate protein synthesis via signaling through type 1 receptors which are homologous to insulin receptors and activate phosphorylation cascades. IGFs enhance the proliferation of chondocytes and the proliferation of their collagen and proteoglycan matrix; IGFs stimulate longitudinal (endochondral) bone growth. Throughout life, IGFs are constitutively expressed ubiquitous factors which help to maintain the survival of differentiated cells, Increased expression is found during growth and tissue repair, Six specific binding proteins, IGFBP 1-6, allow additional tissue compartment specific control of IGF activity; IGFBP production favours storage and IGFBP cleavage leads to activation.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/286637</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1006/cbir.1995.1088</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/7640658</dc:relation>
  <dc:source>Cell biology international. - 1995</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Bone Development</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Carrier Proteins</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Cartilage</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Cell Differentiation</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Cell Division</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Cell Survival</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Collagen</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Dwarfism</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Homeostasis</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Insulin-Like Growth Factor II</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Osteoblasts</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Osteoporosis</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">Proteoglycans</dc:subject>
  <dc:subject xmlns:ns16="xml" ns16:lang="en">Receptor, IGF Type 1</dc:subject>
  <dc:subject xmlns:ns17="xml" ns17:lang="en">Receptor, IGF Type 2</dc:subject>
  <dc:subject xmlns:ns18="xml" ns18:lang="en">Wound Healing</dc:subject>
  <dc:title xmlns:ns19="xml" ns19:lang="en">Insulin-like growth factors.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>