<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Kempf W</dc:creator>
  <dc:creator>Adams V</dc:creator>
  <dc:creator>Kleinhans M</dc:creator>
  <dc:creator>Burg G</dc:creator>
  <dc:creator>Panizzon RG</dc:creator>
  <dc:creator>Campadelli-Fiume G</dc:creator>
  <dc:creator>Nestle FO</dc:creator>
  <dc:date>1999</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">OBJECTIVE
To examine the proposed association between pityriasis rosea and human herpesvirus 7 (HHV-7).


DESIGN
A retrospective cross-sectional survey.


SETTING
University medical center in Switzerland.


PATIENTS
Thirteen patients with pityriasis rosea and 14 persons with normal skin (control subjects).


MAIN OUTCOME MEASURES
Detection of HHV-7-specific DNA sequences and antigen (85-kd phosphoprotein [pp85]) by nested polymerase chain reaction and immunohistochemical analysis, respectively.


RESULTS
Human herpesvirus 7 DNA sequences and expression of the HHV-7-specific immunodominant pp85 antigen were found in 1 (8%) of 13 lesional skin biopsy specimens of pityriasis rosea. The prevalence of HHV-7 DNA sequences and antigens is even slightly lower in lesional skin of patients with pityriasis rosea than in clinically and morphologically normal skin of 14 control persons, in 2 of whom (14%) HHV-7 DNA sequences and antigens could be detected.


CONCLUSION
The low detection rate of HHV-7 DNA sequences and antigens argues strongly against a causative role for HHV-7 in the pathogenesis of pityriasis rosea.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/286823</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1001/archderm.135.9.1070</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/10490111</dc:relation>
  <dc:source>Archives of dermatology. - 1999</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Adolescent</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Adult</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Antigens, Viral</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Biopsy</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Cross-Sectional Studies</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">DNA, Viral</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Herpesvirus 7, Human</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Humans</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Middle Aged</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Pityriasis Rosea</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Retrospective Studies</dc:subject>
  <dc:title xmlns:ns12="xml" ns12:lang="en">Pityriasis rosea is not associated with human herpesvirus 7.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>