Locher R Weisser B Mengden T Brunner C Vetter W 1992 Oxidation of low density lipoprotein increases its atherogenic potential. During oxidation there is an extensive conversion of lecithin to lysolecithin. In rat aortic smooth muscle cells, 2-25 micrograms/ml lysolecithin elevated cytosolic calcium concentration up to 560%. Lysolecithin (10-20 micrograms/ml) increased [3H]thymidine incorporation from 15 cpm/mg cell protein (controls) up to 189 cpm/mg cell protein. Lysolecithin (10 micrograms/ml) potentiated the PDGF-induced (50 ng/ml) [3H]thymidine incorporation up to 6.3 times. The results indicate that lysolecithin could induce mechanisms, by which oxidized low density lipoproteins could promote cell growth and thus contribute to atherosclerosis. https://sonar.ch/global/documents/286854 eng info:eu-repo/semantics/altIdentifier/doi/10.1016/0006-291x(92)91622-w info:eu-repo/semantics/altIdentifier/pmid/1543486 Biochemical and biophysical research communications. - 1992 Animals Aorta Calcium Cell Division Cells, Cultured Cytosol Dose-Response Relationship, Drug Female Lysophosphatidylcholines Muscle, Smooth, Vascular Platelet-Derived Growth Factor Rats Lysolecithin actions on vascular smooth muscle cells. http://purl.org/coar/resource_type/c_6501