Bachmann M Kukkurainen S Hytönen VP Wehrle-Haller B 2019 Integrins are heterodimeric cell surface receptors ensuring the mechanical connection between cells and the extracellular matrix. In addition to the anchorage of cells to the extracellular matrix, these receptors have critical functions in intracellular signaling, but are also taking center stage in many physiological and pathological conditions. In this review, we provide some historical, structural, and physiological notes so that the diverse functions of these receptors can be appreciated and put into the context of the emerging field of mechanobiology. We propose that the exciting journey of the exploration of these receptors will continue for at least another new generation of researchers. application/pdf https://sonar.ch/global/documents/287852 eng info:eu-repo/semantics/altIdentifier/doi/10.1152/physrev.00036.2018 info:eu-repo/semantics/altIdentifier/pmid/31313981 info:eu-repo/semantics/openAccess Physiological reviews. - 2019 cell adhesion fibronectin integrin mechanosensing talin Adaptor Proteins, Signal Transducing Animals Cell Adhesion Cell Membrane Cell Proliferation Extracellular Matrix Humans Integrins Intracellular Signaling Peptides and Proteins Mechanotransduction, Cellular Models, Molecular Phosphoproteins Protein Conformation Structure-Activity Relationship Transcription Factors Cell Adhesion by Integrins. http://purl.org/coar/resource_type/c_6501