<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Poirel L</dc:creator>
  <dc:creator>Kieffer N</dc:creator>
  <dc:creator>Nordmann P</dc:creator>
  <dc:date>2017</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">The plasmid-mediated mcr-1 gene encodes a phosphoethanolamine transferase that confers resistance to polymyxins. The mcr-1 gene is associated with insertion sequence ISApl1 (IS30 family). In vitro mobilization assays demonstrated the functionality of the composite transposon structure ISApl1-mcr-1-ISApl1 Transposition generated a 2-bp duplication and occurred in AT-rich DNA regions. This is the first report demonstrating the mobility of the mcr-1 gene by transposition.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://sonar.ch/global/documents/290351</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.00127-17</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/28416554</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:source>Antimicrobial agents and chemotherapy. - 2017</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">ISApl1</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">composite transposon</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">mcr-1</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">plasmid</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">polymyxins</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">transposition</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Anti-Bacterial Agents</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Colistin</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">DNA Transposable Elements</dc:subject>
  <dc:subject xmlns:ns10="xml" ns10:lang="en">Drug Resistance, Bacterial</dc:subject>
  <dc:subject xmlns:ns11="xml" ns11:lang="en">Gene Duplication</dc:subject>
  <dc:subject xmlns:ns12="xml" ns12:lang="en">Microbial Sensitivity Tests</dc:subject>
  <dc:subject xmlns:ns13="xml" ns13:lang="en">Plasmids</dc:subject>
  <dc:subject xmlns:ns14="xml" ns14:lang="en">Polymyxins</dc:subject>
  <dc:subject xmlns:ns15="xml" ns15:lang="en">Sequence Analysis, DNA</dc:subject>
  <dc:title xmlns:ns16="xml" ns16:lang="en">In Vitro Study of ISApl1-Mediated Mobilization of the Colistin Resistance Gene mcr-1.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>