<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Borbély AA</dc:creator>
  <dc:creator>Trachsel L</dc:creator>
  <dc:creator>Tobler I</dc:creator>
  <dc:date>1988</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Ritanserin (1.0 and 2.5 mg/kg i.p.) was administered to rats before the start, of the light period, and sleep was recorded during the subsequent 12 h. The higher dose reduced sleep in the first 3 h. Both doses caused a more prolonged suppression of REM sleep. Spectral analysis of the EEG in non-REM sleep showed an increase of power density in the low frequency range (1.5-6 Hz) and a depression in the high frequency range (8-25 Hz). Since these changes differ from those previously observed after sleep deprivation, it is premature to conclude that the drug induces a physiological sleep intensification.</dc:description>
  <dc:identifier>https://sonar.ch/global/documents/3049</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/0014-2999(88)90332-9</dc:relation>
  <dc:relation>info:eu-repo/semantics/altIdentifier/pmid/3149244</dc:relation>
  <dc:source>European journal of pharmacology. - 1988</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Animals</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Dose-Response Relationship, Drug</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Electroencephalography</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Male</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Piperidines</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">Rats</dc:subject>
  <dc:subject xmlns:ns7="xml" ns7:lang="en">Rats, Inbred Strains</dc:subject>
  <dc:subject xmlns:ns8="xml" ns8:lang="en">Ritanserin</dc:subject>
  <dc:subject xmlns:ns9="xml" ns9:lang="en">Sleep Stages</dc:subject>
  <dc:title xmlns:ns10="xml" ns10:lang="en">Effect of ritanserin on sleep stages and sleep EEG in the rat.</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>